三代试管移植前还要做什么检查
在三代试管婴儿（PGT，胚胎植入前遗传学检测）移植前，为确保胚胎质量和母体适合妊娠，通常需要进行以下检查：一、胚胎相关检查[*]PGT结果确认
[*]核对胚胎的遗传学检测报告（如PGT-A/PGT-M/PGT-SR），确保筛选后的胚胎无异常。
[*]胚胎发育评估
[*]检查胚胎的形态学评分、囊胚等级（如4AA、5BB等）及发育速度。
二、母体健康检查
[*]子宫评估
[*]宫腔镜：排查内膜息肉、粘连、炎症等。
[*]超声检查：测量内膜厚度（理想≥7mm）、形态（三线征最佳）、血流情况。
[*]内膜容受性检测（ERA）：必要时评估最佳移植窗口期。
[*]激素水平
[*]雌激素（E2）、孕酮（P）、促黄体生成素（LH）等，确保激素水平适合移植。
[*]感染性疾病筛查
[*]乙肝、丙肝、梅毒、HIV等复查（部分医院要求3个月内有效报告）。
[*]凝血功能
[*]凝血酶原时间（PT）、D-二聚体等，预防血栓风险。
[*]免疫检查（部分反复失败者需查）
[*]抗磷脂抗体、NK细胞活性、封闭抗体等。
三、全身健康状况
[*]常规检查
[*]血常规、尿常规、肝肾功能、血糖、甲状腺功能（TSH、FT4）。
[*]慢性病管理
[*]如有高血压、糖尿病等，需控制稳定后再移植。
四、移植前准备
[*]用药调整
[*]根据方案使用黄体支持（如孕酮）、雌激素等药物，模拟自然周期或人工周期。
[*]身体调理
[*]避免吸烟、饮酒，保持适度运动，减少压力。
[*]签署知情同意书
[*]确认胚胎数目、移植风险、剩余胚胎处理方式等。
五、其他注意事项
[*]时间安排：检查通常在月经周期特定时间进行（如内膜检查在排卵后）。
[*]既往病史：如有复发性流产或移植失败史，可能需额外检查（如免疫、血栓倾向筛查）。
建议与生殖中心密切沟通，个体化调整检查清单。移植前的完善评估能显著提高成功率！
Before the transfer of third-generation test tube baby (PGT, pre implantation genetic testing), the following tests are usually required to ensure embryo quality and maternal suitability for pregnancy:1、 Embryo related examinationsPGT result confirmationVerify the genetic testing report of the embryos (such as PGT-A/PGT-M/PGT-SR) to ensure that the screened embryos have no abnormalities.Embryo Development AssessmentCheck the morphological score, blastocyst grade (such as 4AA, 5BB, etc.), and developmental rate of the embryo.2、 Maternal health examinationUterine evaluationHysteroscopy: Check for endometrial polyps, adhesions, inflammation, etc.Ultrasound examination: Measure endometrial thickness (ideally ≥ 7mm), morphology (best trilinear sign), and blood flow.Endometrial receptivity testing (ERA): evaluate the optimal transplant window period if necessary.Hormone levelsEstrogen (E2), progesterone (P), luteinizing hormone (LH), etc., ensure hormone levels are suitable for transplantation.Infectious diseases screeningRe examination of hepatitis B, hepatitis C, syphilis, HIV, etc. (some hospitals require effective reports within 3 months).blood clottingProthrombin time (PT), D-dimer, etc. are used to prevent the risk of thrombosis.Immune examination (some repeated failures need to be checked)Antiphospholipid antibodies, NK cell activity, blocking antibodies, etc.3、 General health conditionRoutine inspectionBlood routine, urine routine, liver and kidney function, blood glucose, thyroid function (TSH, FT4).chronic disease managementIf there is hypertension, diabetes, etc., it needs to be controlled and stabilized before transplantation.4、 Preparation before transplantationMedication adjustmentAccording to the plan, use luteal support (such as progesterone), estrogen and other drugs to simulate natural or artificial cycles.Body conditioningAvoid smoking and drinking alcohol, maintain moderate exercise, and reduce stress.Sign informed consent formConfirm the number of embryos, transfer risk, and remaining embryo handling methods.5、 Other precautionsTime schedule: The examination is usually conducted at a specific time during the menstrual cycle (such as endometrial examination after ovulation).Medical history: If there is a history of recurrent miscarriage or transplant failure, additional examinations (such as immunological and thrombophilia screening) may be necessary.Suggest close communication with the reproductive center and individualized adjustment of the checklist. A comprehensive evaluation before transplantation can significantly improve the success rate!
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